Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PNLIP | P16233 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207646 | 0.72 | KDM4C (0.41) | POLBMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL5202998 | 0.72 | LTA4H (0.57) | MAPTCYP1A2CYP2C9CYP2C19SCN9A | |
| SCHEMBL7712456 | 0.72 | MEN1 (0.44) | MAPTHTT | |
| Methane SCHEMBL7708438 | 0.71 | KDM4C (0.40) | POLBMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL7708436 | 0.69 | LMNA (0.52) | POLBLMNANPSR1 | |
| SCHEMBL7716750 | 0.69 | KDM4C (0.40) | CYP1A2CYP2C9CYP2C19HTTNPSR1 | |
| SCHEMBL5175115 | 0.65 | MAOA (0.58) | MAPTLMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7712513 | 0.63 | HRH4 (0.49) | POLBCYP1A2 | |
| SCHEMBL7716633 | 0.63 | KMT2A (0.49) | CYP1A2CYP2C9CYP2C19HTTNPSR1 | |
| SCHEMBL3350998 | 0.63 | SOS1 (0.44) | POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |