Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 7/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202998 | 0.84 | LTA4H (0.57) | LTA4HKDM4C | |
| SCHEMBL7712501 | 0.84 | XDH (0.45) | LTA4H | |
| SCHEMBL5202653 | 0.84 | TEAD4 (0.42) | NPBWR1MCHR1LTA4HICAM1SELE | |
| SCHEMBL5207820 | 0.82 | MAPT (0.43) | LTA4HICAM1SELEDHFRAURKA | |
| SCHEMBL7712456 | 0.81 | MEN1 (0.44) | LTA4HICAM1SELEAURKA | |
| SCHEMBL5206240 | 0.80 | NOS1 (0.45) | LTA4HKDM4C | |
| SCHEMBL5204052 | 0.80 | SMN1; SMN2 (0.42) | NPBWR1MCHR1LTA4HICAM1SELE | |
| SCHEMBL5206874 | 0.77 | L3MBTL1 (0.41) | LTA4HICAM1SELEKDM4C | |
| SCHEMBL7712398 | 0.77 | TYMS (0.43) | LTA4HKDM4C | |
| SCHEMBL5204487 | 0.74 | SOS1 (0.40) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |