Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 12/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 12/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714185 | 0.81 | CYP11B1 (0.44) | CYP11B1CYP11B2FNTAFNTBCACNA1H | |
| SCHEMBL7936017 | 0.72 | CYP11B1 (0.41) | CYP11B1CYP11B2CACNA1H | |
| SCHEMBL7714943 | 0.72 | CYP11B1 (0.38) | CYP11B1CYP11B2FNTAFNTBSLC22A12 | |
| SCHEMBL6928397 | 0.72 | TRPV4 (0.42) | CYP11B1CYP11B2CACNA1H | |
| SCHEMBL3578566 | 0.71 | CYP11B1 (0.41) | CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL1097392 | 0.71 | HTR1A (0.30) | — | |
| SCHEMBL7715279 | 0.69 | DAO (0.43) | CYP11B1CYP11B2CACNA1H | |
| SCHEMBL3568025 | 0.68 | HTT (0.50) | CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL1097299 | 0.66 | CYP19A1 (0.42) | CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL8195498 | 0.66 | CYP11B1 (0.44) | CYP11B1CYP11B2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |