Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | ACR | P10323 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10732623 | 0.69 | PRSS1 (0.52) | PRSS1ACRGAAPPARGPPARA | |
| SCHEMBL11370912 | 0.66 | ATM (0.41) | PRSS1ACRGAAPPARGPPARA | |
| SCHEMBL1255890 | 0.65 | ELANE (0.47) | KDM4EALDH1A1 | |
| SCHEMBL4658587 | 0.65 | AKR1C3 (0.51) | SMN1; SMN2KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10946374 | 0.64 | ELANE (0.46) | KDM4EALDH1A1 | |
| SCHEMBL7715202 | 0.63 | MGLL (0.38) | ALDH1A1 | |
| SCHEMBL20528635 | 0.62 | SMN1; SMN2 (0.44) | SMN1; SMN2KMT2AMEN1GAALMNA | |
| SCHEMBL10180800 | 0.62 | ESR1 (0.49) | KMT2AMEN1PPARGPPARAALDH1A1 | |
| SCHEMBL11436506 | 0.62 | CYP3A4 (0.59) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL27284217 | 0.61 | PARP1 (0.57) | KMT2AMEN1PRSS1ACREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |