Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MME | P08473 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5305401 | 0.80 | LMNA (0.60) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5335651 | 0.77 | LMNA (0.57) | GAAALDH1A1MEN1KMT2ALMNA | |
| Iodide SCHEMBL7715449 | 0.77 | L3MBTL1 (0.58) | GAAALDH1A1MEN1KMT2ALMNA | |
| Bicarbonate SCHEMBL27963003 | 0.75 | HTR1A (0.61) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5092381 | 0.73 | GAA (0.67) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3040254 | 0.73 | DPP7 (0.45) | GAAALDH1A1MMEACECPA1 | |
| SCHEMBL10712905 | 0.73 | LMNA (0.64) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1894256 | 0.73 | HTR1A (0.67) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL19001344 | 0.72 | GAA (0.97) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5092378 | 0.72 | LMNA (0.66) | GAAALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |