Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3782773 | 0.82 | MAPT (0.62) | MAPTTDP1CNR2RAB9A | |
| SCHEMBL6704275 | 0.79 | ALDH1A1 (0.40) | MAPTTDP1S1PR3CNR2 | |
| SCHEMBL3245118 | 0.78 | CTSV (0.50) | MAPTTDP1NPC1CYP2C9RAB9A | |
| SCHEMBL4047895 | 0.78 | KDM4E (0.53) | TDP1NPC1RAB9A | |
| SCHEMBL8787570 | 0.77 | LMNA (0.47) | MAPTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6437034 | 0.76 | TDP1 (0.47) | MAPTTDP1 | |
| SCHEMBL7348961 | 0.75 | MAPT (0.60) | MAPTTDP1 | |
| SCHEMBL18468544 | 0.75 | HSD17B10 (0.47) | MAPTTDP1 | |
| SCHEMBL2540541 | 0.75 | KDM4E (0.47) | MAPTTDP1 | |
| SCHEMBL14699866 | 0.74 | CNR2 (0.52) | MAPTTDP1PTPN11S1PR3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002087587-A2 | 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |