Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5444623 | 0.87 | TDP1 (0.50) | MAPTTDP1ALDH1A1PDE4DLMNA | |
| SCHEMBL13607855 | 0.86 | MAPT (0.57) | MAPTTDP1ALDH1A1PDE4DPPARG | |
| SCHEMBL19705421 | 0.86 | MAPT (0.51) | MAPTTDP1ALDH1A1PPARGPPARA | |
| Hydrochloric Acid SCHEMBL6437034 | 0.86 | TDP1 (0.47) | MAPTTDP1ALDH1A1PPARGPPARA | |
| SCHEMBL13285652 | 0.85 | MAPT (0.47) | MAPTTDP1ALDH1A1PPARGPPARA | |
| SCHEMBL7348961 | 0.85 | MAPT (0.60) | MAPTTDP1ALDH1A1PDE4DPPARG | |
| SCHEMBL3785672 | 0.85 | MAPT (0.60) | MAPTTDP1ALDH1A1PDE4DPPARG | |
| SCHEMBL7274826 | 0.84 | MAPT (0.55) | MAPTTDP1ALDH1A1PDE4DPPARG | |
| SCHEMBL28349799 | 0.83 | MAPT (0.57) | MAPTTDP1ALDH1A1PDE4DLMNA | |
| SCHEMBL8388024 | 0.83 | TDP1 (0.45) | MAPTTDP1ALDH1A1PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220265845-A1 | AMINOTHIOLESTER COMPOUNDS AND USES THEREOF | ADVANCED BIODESIGN (FR) | 2022-08-25 | — | — | US | disclosed |
| US-9408852-B2 | Method of lowering serum uric acid levels with (S)-tofisopam | PHARMOS CORPORATION (US) | 2016-08-09 | — | — | US | disclosed |
| EP-1807408-B1 | OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS | COUNCIL SCIENT IND RES (IN) | 2016-06-08 | — | — | EP | disclosed |
| US-8455540-B2 | Gossypol and apogossypol derivatives, preparation thereof and uses thereof | UNIVERSITE DU MAINE (LE MANS) (FR) | 2013-06-04 | — | — | US | disclosed |
| US-20130045966-A1 | Method of Lowering Serum Uric Acid Levels With (S)-Tofisopam | PHARMOS CORPORATION (US) | 2013-02-21 | — | — | US | disclosed |
| US-20100331398-A1 | DERIVES DU GOSSYPOL ET DE L'APOGOSSYPOL, LEURS PREPARATIONS ET LEURS APPLICTIONS | UNIVERSITE DU MAINE (LE MANS) (FR) | 2010-12-30 | — | — | US | disclosed |
| US-7635779-B2 | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2009-12-22 | — | — | US | disclosed |
| EP-1807408-A1 | OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS | Council of Scientific and Industrial Research (IN) | 2007-07-18 | — | — | EP | disclosed |
| US-20060178373-A1 | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2006-08-10 | — | — | US | disclosed |
| WO-2006040621-A1 | OXY SUBSTITUTED FLAVONES AS ANTIHYPERGLYCEMIC AND ANTIDYSLIPIDEMIC AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-04-20 | — | — | WO | disclosed |
| US-20040229866-A1 | Method of lowering body temperature with (S)-2,3-benzodiazepines | VELA PHARMACEUTICALS, INC. | 2004-11-18 | — | — | US | disclosed |
| US-20040224943-A1 | Method of lowering body temperature with (R) - 2,3-benzodiazepines | VELA ACQUISITION CORPORATION | 2004-11-11 | — | — | US | disclosed |
| WO-2004073638-A2 | METHOD OF LOWERING BODY TEMPERATURE WITH (S)-2,3-BENZODIAZEPINES | VELA PHARMACEUTICALS, INC. (US) | 2004-09-02 | — | — | WO | disclosed |
| US-20040162284-A1 | Method of lowering body temperature with (S) tofisopam | VELA ACQUISITION CORPORATION | 2004-08-19 | — | — | US | disclosed |
| US-4910206-A | Endotoxin induced lung injury | SANDOZ PHARMACEUTICALS CORP. (US) | 1990-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229866-A1 | Method of lowering body temperature with (S)-2,3-benzodiazepines | CYP11B2, CYP2S1, CYP1A2 | MAPT 3258/4885TDP1 2889/4885ALDH1A1 255/4885 |
| US-20220265845-A1 | AMINOTHIOLESTER COMPOUNDS AND USES THEREOF | AADAT, DNPEP, AASDHPPT | MAPT 19/4885TDP1 2995/4885ALDH1A1 690/4885 |
| US-20040224943-A1 | Method of lowering body temperature with (R) - 2,3-benzodiazepines | GABBR1, GABBR2, CYP11B2 | MAPT 3294/4885TDP1 2223/4885ALDH1A1 244/4885 |
| US-20060178373-A1 | Oxy substituted flavones as antihyperglycemic and antidyslipidemic agents | GPR119, LIPC, SLC5A2 | MAPT 4774/4885TDP1 3159/4885ALDH1A1 2333/4885 |
| US-20130045966-A1 | Method of Lowering Serum Uric Acid Levels With (S)-Tofisopam | ATIC, NPPA, XPNPEP1 | MAPT 3965/4885TDP1 1281/4885ALDH1A1 1253/4885 |
| US-20040162284-A1 | Method of lowering body temperature with (S) tofisopam | THOP1, SHBG, NPPA | MAPT 4059/4885TDP1 1660/4885ALDH1A1 2648/4885 |
| US-20100331398-A1 | DERIVES DU GOSSYPOL ET DE L'APOGOSSYPOL, LEURS PREPARATIONS ET LEURS APPLICTIONS | LSS, GRHPR, NR1H3 | MAPT 2563/4885TDP1 1282/4885ALDH1A1 2349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.