Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713660 | 0.73 | NOS3 (0.46) | PLAUKCNA5KCNH2KDM4ELMNA | |
| SCHEMBL609343 | 0.67 | LMNA (0.36) | KCNA5KCNH2KDM4ELMNANOS1 | |
| SCHEMBL7718559 | 0.67 | CTDSP1 (0.33) | — | |
| SCHEMBL2105197 | 0.64 | — | — | |
| SCHEMBL1673488 | 0.64 | — | — | |
| SCHEMBL5509601 | 0.63 | NOS3 (0.41) | LMNANOS3NOS1NOS2HTT | |
| SCHEMBL4991454 | 0.63 | — | — | |
| SCHEMBL29919450 | 0.62 | HDAC8 (0.39) | KDM4ELMNANOS3NOS1NOS2 | |
| SCHEMBL2469365 | 0.62 | HDAC8 (0.39) | KDM4ELMNANOS3NOS1NOS2 | |
| SCHEMBL1352941 | 0.62 | HSP90AA1 (0.39) | PLAUKDM4ELMNANOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002087587-A2 | 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |