Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603664 | 0.88 | NOS3 (0.44) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL1629938 | 0.83 | — | — | |
| SCHEMBL1850348 | 0.79 | ADRA2A (0.48) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL10634493 | 0.79 | ADRA2A (0.44) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL1851035 | 0.79 | ADRA2A (0.40) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL2235378 | 0.75 | NOS3 (0.42) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL7718559 | 0.73 | CTDSP1 (0.33) | — | |
| SCHEMBL1850336 | 0.73 | MAOA (0.46) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL1849181 | 0.73 | HRH3 (0.44) | NOS3NOS1NOS2ADRA2AADRA2B | |
| SCHEMBL7718563 | 0.73 | PLAU (0.32) | NOS3NOS1NOS2PLAULMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002087587-A2 | 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |