Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL8112269 | 0.85 | HIF1A (0.40) | CA2SMN1; SMN2CXCR4TSHRGABRP | |
| Piperidine SCHEMBL4577836 | 0.82 | ALDH1A1 (0.64) | ALDH1A1CA2CHKASMN1; SMN2CXCR4 | |
| Azepane SCHEMBL714889 | 0.82 | ALDH1A1 (0.64) | ALDH1A1CA2CHKASMN1; SMN2CXCR4 | |
| Piperidine SCHEMBL720107 | 0.82 | ALDH1A1 (0.64) | ALDH1A1CA2CHKASMN1; SMN2CXCR4 | |
| Cyclopropane SCHEMBL11399095 | 0.82 | FFAR3 (0.38) | CA2 | |
| SCHEMBL6374475 | 0.82 | FFAR3 (0.38) | CA2 | |
| Cyclohexane SCHEMBL9535898 | 0.82 | FFAR3 (0.38) | CA2 | |
| Cyclopropane SCHEMBL4440814 | 0.82 | FFAR3 (0.38) | CA2 | |
| Cyclopentane SCHEMBL7058888 | 0.82 | FFAR3 (0.38) | CA2 | |
| Cyclohexane SCHEMBL1985260 | 0.82 | FFAR3 (0.38) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380220-B1 | THERAPY OF NEURODEGENERATIVE DISEASES AND NEURONAL INJURIES WHICH ARE CASUED BY ISCHEMIA, TRAUMA OR MASSIVE HEMORRHAGES | ABBOTT LABORATORIES | 2002-04-30 | — | — | US | claimed |
| US-6380220-B1 | THERAPY OF NEURODEGENERATIVE DISEASES AND NEURONAL INJURIES WHICH ARE CASUED BY ISCHEMIA, TRAUMA OR MASSIVE HEMORRHAGES | ABBOTT LABORATORIES | 2002-04-30 | — | — | US | disclosed |
| US-6380220-B1 | THERAPY OF NEURODEGENERATIVE DISEASES AND NEURONAL INJURIES WHICH ARE CASUED BY ISCHEMIA, TRAUMA OR MASSIVE HEMORRHAGES | ABBOTT LABORATORIES | 2002-04-30 | — | — | US | disclosed |
| WO-2001039792-A2 | THE USE OF CASPASE 9 INHIBITORS TO TREAT OCULAR NEURAL PATHOLOGY | ALCON UNIVERSAL LTD. (CH) | 2001-06-07 | — | — | WO | disclosed |
| CN-1239950-A | New derivates from piperidine-keto acid, their preparation and use | BASF AG (DE) | 1999-12-29 | — | — | CN | disclosed |