Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL4577836 | 1.00 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Azepane SCHEMBL714889 | 1.00 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Azepane SCHEMBL20740115 | 0.97 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Azepane SCHEMBL940042 | 0.97 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Pyrrolidine SCHEMBL712847 | 0.96 | — | — | |
| Piperidine SCHEMBL5875101 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Piperidine SCHEMBL2483462 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Azetidine SCHEMBL7551428 | 0.89 | — | — | |
| Piperidine SCHEMBL10332243 | 0.87 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Piperidine SCHEMBL9400727 | 0.87 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546100-B1 | NEW BENZOYL PIPERIDINE COMPOUNDS | SK HOLDINGS CO LTD (KR) | 2011-04-20 | — | — | EP | claimed |
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | SHISEIDO COMPANY LTD. (JP) | 2007-09-27 | — | — | US | claimed |
| EP-1688126-A1 | PARAKERATOSIS INHIBITOR AND EXTERNAL COMPOSITION FOR SKIN | SHISEIDO COMPANY LIMITED (JP) | 2006-08-09 | — | — | EP | claimed |
| EP-1102538-A1 | PLANT GROWTH REGULATOR COMPOSITIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-05-30 | — | — | EP | claimed |
| WO-1999052368-A1 | PLANT GROWTH REGULATOR COMPOSITIONS | BASF AKTIENGESELLSCHAFT (DE) | 1999-10-21 | — | — | WO | claimed |
| EP-0024382-B1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | af Ekenstam, Bo (SE) | 1984-03-07 | — | — | EP | claimed |
| EP-0024382-A1 | Piperidine derivatives, their preparation and pharmaceutical compositions containing them | af Ekenstam, Bo (SE) | 1981-03-04 | — | — | EP | claimed |
| WO-2024221494-A1 | CATALYST, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海凯赛生物技术股份有限公司 | 2024-10-31 | — | — | WO | disclosed |
| CN-118847119-A | Catalyst and preparation method and application thereof | 上海凯赛生物技术股份有限公司 | 2024-10-29 | — | — | CN | disclosed |
| US-10821196-B2 | Substrate based PET imaging agents | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2020-11-03 | — | — | US | disclosed |
| CN-109293517-A | The method for preparing template | 庄信万丰股份有限公司 | 2019-02-01 | — | — | CN | disclosed |
| EP-2279011-B1 | SUBSTRATE BASED PET IMAGING AGENTS | SIEMENS MEDICAL SOLUTIONS USA INC (US) | 2017-10-25 | — | — | EP | disclosed |
| US-20150182643-A1 | Novel Substrate Based PET Imaging Agents | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2015-07-02 | — | — | US | disclosed |
| US-5089378-A | Method for forming an image | FUJI PHOTO FILM CO., LTD. (JP) | 1992-02-18 | — | — | US | disclosed |
| EP-0465078-A1 | Infra-red sensitive photographic materials | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1992-01-08 | — | — | EP | disclosed |
| EP-0426087-A2 | Dye fixing material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-05-08 | — | — | EP | disclosed |
| US-4729942-A | PREVENTING EARLY COLOR DIFFUSION BY USING A DYE DEVELOPER HAVING A DYE MOITY HAVING A HYDROLYZABLE ESTER BALLAST GROUP; PHOTOTHERMOGRAPHY; SILVER HALIDES; | FUJI PHOTO FILM CO., LTD. (JP) | 1988-03-08 | — | — | US | disclosed |
| US-4704345-A | COLOR PHOTOGRAPHY, DIFFUSION TRANSFER, THERMOGRAPHY | FUJI PHOTO FILM CO., LTD. (JP) | 1987-11-03 | — | — | US | disclosed |
| EP-0024382-B1 | PIPERIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | af Ekenstam, Bo (SE) | 1984-03-07 | — | — | EP | disclosed |
| EP-0024382-A1 | Piperidine derivatives, their preparation and pharmaceutical compositions containing them | af Ekenstam, Bo (SE) | 1981-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10821196-B2 | Substrate based PET imaging agents | MPI, PIGO, SLC35B2 | ALDH1A1 2040/4885SMN1; SMN2 3767/4885CXCR4 2786/4885 |
| US-20150182643-A1 | Novel Substrate Based PET Imaging Agents | MPI, PIGO, SLC35B2 | ALDH1A1 2429/4885SMN1; SMN2 4207/4885CXCR4 2471/4885 |
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | CUTA, HPN, DNPEP | ALDH1A1 3008/4885SMN1; SMN2 4072/4885CXCR4 4314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.