Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azepane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL4577836 | 1.00 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Piperidine SCHEMBL720107 | 1.00 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Azepane SCHEMBL20740115 | 0.97 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Azepane SCHEMBL940042 | 0.97 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Pyrrolidine SCHEMBL712847 | 0.96 | — | — | |
| Piperidine SCHEMBL5875101 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Piperidine SCHEMBL2483462 | 0.90 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Azetidine SCHEMBL7551428 | 0.89 | — | — | |
| Piperidine SCHEMBL10332243 | 0.87 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA | |
| Piperidine SCHEMBL9400727 | 0.87 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2CXCR4CA2CHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | SHISEIDO COMPANY LTD. (JP) | 2007-09-27 | — | — | US | claimed |
| EP-1688126-A1 | PARAKERATOSIS INHIBITOR AND EXTERNAL COMPOSITION FOR SKIN | SHISEIDO COMPANY LIMITED (JP) | 2006-08-09 | — | — | EP | claimed |
| EP-3444089-B1 | PREPREG, FIBER-REINFORCED COMPOSITE MATERIAL AND SURFACE-MODIFIED REINFORCING FIBERS | TEIJIN LTD (JP) | 2024-02-28 | — | — | EP | disclosed |
| CN-115280556-A | Conductive material dispersion liquid, positive electrode for lithium ion secondary battery using same, and method for producing lithium ion secondary battery | 御国色素株式会社 | 2022-11-01 | — | — | CN | disclosed |
| US-11352472-B2 | Prepreg, fiber-reinforced composite material and surface-modified reinforcing fibers | TEIJIN LIMITED (JP) | 2022-06-07 | — | — | US | disclosed |
| US-9299483-B2 | Method for manufacturing transparent conductive film | INKTEC CO., LTD. (KR) | 2016-03-29 | — | — | US | disclosed |
| US-9290844-B2 | Method for preparing metallic thin film | INKTEC CO., LTD. (KR) | 2016-03-22 | — | — | US | disclosed |
| US-8586638-B2 | Parakeratosis inhibitor and skin preparation for external use | SHISEIDO COMPANY, LTD (JP) | 2013-11-19 | — | — | US | disclosed |
| US-20130118786-A1 | Method for Manufacturing Transparent Conductive Film and Transparent Conductive Film Manufactured Thereby | INKTEC CO., LTD. (KR) | 2013-05-16 | — | — | US | disclosed |
| US-20120253064-A1 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE | SHISEIDO COMPANY, LTD. (JP) | 2012-10-04 | — | — | US | disclosed |
| EP-2491980-A2 | Parakeratosis inhibitor and skin preparation for external use | SHISEIDO COMPANY LIMITED (JP) | 2012-08-29 | — | — | EP | disclosed |
| EP-2491981-A2 | Parakeratosis inhibitor and external composition for skin | SHISEIDO COMPANY LIMITED (JP) | 2012-08-29 | — | — | EP | disclosed |
| US-20120053243-A1 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE | SHISEIDO COMPANY, LTD. (JP) | 2012-03-01 | — | — | US | disclosed |
| US-20110318481-A1 | Method for Preparing Metallic Thin Film | INKTEC CO., LTD. (KR) | 2011-12-29 | — | — | US | disclosed |
| WO-2009075520-A1 | A METHOD FOR FABRICATING BLACKENED CONDUCTIVE PATTERNS | INKTEC CO., LTD. (KR) | 2009-06-18 | — | — | WO | disclosed |
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | SHISEIDO COMPANY LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1688126-A1 | PARAKERATOSIS INHIBITOR AND EXTERNAL COMPOSITION FOR SKIN | SHISEIDO COMPANY LIMITED (JP) | 2006-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053243-A1 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE | CUTA, HPN, DNPEP | ALDH1A1 3008/4885SMN1; SMN2 4072/4885CXCR4 4314/4885 |
| US-20120253064-A1 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE | CUTA, HPN, PRSS1 | ALDH1A1 3879/4885SMN1; SMN2 4493/4885CXCR4 4674/4885 |
| US-20070225380-A1 | Parakeratosis Inhibitor and Skin Preparation for External use | CUTA, HPN, DNPEP | ALDH1A1 3008/4885SMN1; SMN2 4072/4885CXCR4 4314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.