Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | PLEC | Q15149 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7713852 | 0.99 | PRSS1 (0.35) | PRSS1PTGER4 | |
| SCHEMBL8104786 | 0.99 | PRSS1 (0.35) | PRSS1PTGER4HDAC6KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7718297 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL7717328 | 0.78 | — | — | |
| SCHEMBL8104847 | 0.77 | TSHR (0.30) | — | |
| Hydrochloric Acid SCHEMBL7721076 | 0.77 | ALDH1A1 (0.32) | KDM4EALDH1A1GAAMAPTHPGD | |
| SCHEMBL8104608 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL5481941 | 0.76 | KDM4E (0.30) | KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5483280 | 0.76 | MAPT (0.35) | KDM4EALDH1A1GAAMAPTHTT | |
| SCHEMBL8095464 | 0.75 | ALDH1A1 (0.33) | KDM4EALDH1A1GAAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6383230-B1 | COLORFASTNESS, PHOTOSTABILITY, WATERPROOFING, WEATHERPROOFING | L'OREAL (FR) | 2002-05-07 | — | — | US | claimed |
| US-6383230-B1 | COLORFASTNESS, PHOTOSTABILITY, WATERPROOFING, WEATHERPROOFING | L'OREAL (FR) | 2002-05-07 | — | — | US | disclosed |
| JP-2000230133-A | NEW CATIONIC MONOBENZENE DYE, ITS USE FOR DYEING OF KERATIN FIBER, DYEING COMPOSITION AND DYEING METHOD | L'OREAL SA | 2000-08-22 | — | — | JP | disclosed |