Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | HEXA | P06865 | 1/20 | 0.30 |
| ▸ | HEXB | P07686 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7255251 | 0.99 | MAPT (0.35) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL2924185 | 0.99 | MAPT (0.36) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL6570633 | 0.80 | ALDH1A1 (0.47) | MAPTGAATSHRHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7718297 | 0.79 | — | — | |
| Bromide SCHEMBL5718241 | 0.79 | ALDH1A1 (0.47) | MAPTGAATSHRHTTSMN1; SMN2 | |
| SCHEMBL8104847 | 0.78 | TSHR (0.30) | TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL7677754 | 0.77 | LMNA (0.34) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7718845 | 0.76 | PRSS1 (0.34) | MAPTGAAHTTKDM4EALDH1A1 | |
| SCHEMBL7809580 | 0.75 | LMNA (0.35) | MAPTKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL2923345 | 0.75 | APP (0.36) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334713-B1 | Dyeing composition comprising diaminopyrazole and cationic compounds as oxidation bases and a coupling agent | OREAL (FR) | 2005-12-07 | — | — | EP | claimed |
| US-6905522-B2 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | L'OREAL S.A. (FR) | 2005-06-14 | — | — | US | claimed |
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | L'OREAL S.A. (FR) | 2005-05-12 | — | — | US | claimed |
| EP-0928289-B1 | NOVEL CATIONIC OXIDATION BASES, THEIR USE FOR OXIDATION DYEING OF KERATIN FIBRES, DYEING COMPOSITIONS AND DYEING METHODS | OREAL (FR) | 2004-09-29 | — | — | EP | claimed |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRAVTCHENKO SYLVAIN (FR) | 2004-03-11 | — | — | US | claimed |
| US-6638321-B1 | Oxidation color dyes for hair from aniline compounds | L'OREAL (FR) | 2003-10-28 | — | — | US | claimed |
| US-6451067-B1 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-09-17 | — | — | US | claimed |
| US-20070226917-A1 | Hair Dye Agent Comprising Organosilicon Copolymers with Amino Groups and Polyoxyalkylene Groups and Use Thereof | HENKEL KGAA (DE) | 2007-10-04 | — | — | US | disclosed |
| US-7179303-B2 | Active ingredient combinations for hair-dyeing agents | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2007-02-20 | — | — | US | disclosed |
| US-6905522-B2 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | L'OREAL S.A. (FR) | 2005-06-14 | — | — | US | disclosed |
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | L'OREAL S.A. (FR) | 2005-05-12 | — | — | US | disclosed |
| US-20040133996-A1 | Active ingredient combinations for hair-dyeing agents | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-07-15 | — | — | US | disclosed |
| US-20040064901-A1 | Enzymatic coloring agents | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2004-04-08 | — | — | US | disclosed |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRAVTCHENKO SYLVAIN (FR) | 2004-03-11 | — | — | US | disclosed |
| US-6638321-B1 | Oxidation color dyes for hair from aniline compounds | L'OREAL (FR) | 2003-10-28 | — | — | US | disclosed |
| US-6451067-B1 | HAIR DYE MIXTURE | L'OREAL S.A. (FR) | 2002-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040133996-A1 | Active ingredient combinations for hair-dyeing agents | KRT18, COL1A1, MKI67 | MAPT 2503/4885GAA 1489/4885TSHR 4547/4885 |
| US-20040064901-A1 | Enzymatic coloring agents | GLA, HEXA, HSD17B14 | MAPT 2435/4885GAA 49/4885TSHR 4375/4885 |
| US-20050097681-A9 | DYE COMPOSITION COMPRISING AN OXIDATION BASE OF THE DIAMINOPYRAZOLE TYPE, A CATIONIC OXIDATION BASE AND A COUPLER | KRT18, AOC1, CYB5R3 | MAPT 615/4885GAA 4232/4885TSHR 4242/4885 |
| US-20040045100-A1 | Dye composition comprising an oxidation base of the diaminopyrazole type, a cationic oxidation base and a coupler | KRT18, AOC1, CYB5R3 | MAPT 615/4885GAA 4232/4885TSHR 4242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.