Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8706170 | 0.82 | DRD2 (0.34) | DRD2SLC6A3TACR1SLC6A2NR1I2 | |
| SCHEMBL8701939 | 0.81 | TACR1 (0.35) | DRD2SLC6A3TACR1SLC6A2NR1I2 | |
| Hydrochloric Acid SCHEMBL8706566 | 0.81 | DRD2 (0.33) | DRD2SLC6A3TACR1SLC6A2NR1I2 | |
| Hydrochloric Acid SCHEMBL8707886 | 0.80 | TACR1 (0.35) | DRD2SLC6A3TACR1SLC6A2NR1I2 | |
| Hydrochloric Acid SCHEMBL8682543 | 0.77 | CYP1A2 (0.33) | TACR1CYP2D6 | |
| Hydrochloric Acid SCHEMBL8681411 | 0.77 | TACR1 (0.34) | TACR1CYP2D6 | |
| Hydrochloric Acid SCHEMBL8610065 | 0.75 | GRIN1 (0.39) | SLC6A4TACR1SLC6A2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8683249 | 0.75 | CYP1A2 (0.32) | TACR1CYP2D6KMT2A | |
| SCHEMBL8610623 | 0.75 | GRIN1 (0.47) | KDM4ESLC6A4TACR1SLC6A2ALDH1A1 | |
| SCHEMBL8611477 | 0.74 | GRIN1 (0.40) | DRD2SLC6A4TACR1SLC6A2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376507-B1 | NERVE SYSTEM DISORDERS, AMYOTROPIC LATERAL SCLEROSIS | PFIZER INC. | 2002-04-23 | — | — | US | disclosed |