Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 15/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1413883 | 0.80 | ALPL (0.79) | ALPLKDM4EALDH1A1RAB9AKMT2A | |
| SCHEMBL8795088 | 0.78 | HTR6 (0.61) | ALPLKDM4EALDH1A1SLC40A1RAB9A | |
| SCHEMBL15480556 | 0.78 | HDAC6 (0.59) | ALPLKDM4EALDH1A1SLC40A1RAB9A | |
| SCHEMBL5037030 | 0.78 | ATM (0.68) | ALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3061828 | 0.76 | ALPL (0.62) | ALPLKDM4EALDH1A1SLC40A1RAB9A | |
| SCHEMBL2372613 | 0.76 | SLC40A1 (0.57) | ALPLKDM4EALDH1A1SLC40A1RAB9A | |
| SCHEMBL2055422 | 0.75 | ALPL (0.67) | ALPLKDM4EALDH1A1RAB9AKMT2A | |
| SCHEMBL194421 | 0.73 | KEAP1 (0.73) | ALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3448350 | 0.72 | ALPL (0.67) | ALPLKDM4EALDH1A1RAB9AKMT2A | |
| SCHEMBL11973786 | 0.72 | SLC40A1 (1.00) | ALDH1A1SLC40A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355805-B1 | MULTIBINDING COMPOUNDS USEFUL IN TREATMENT AND PREVENTION OF METABOLIC DISORDERS SUCH AS OBESITY AND DIABETES | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |