Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723582 | 0.88 | ALDH1A1 (0.44) | SMN1; SMN2POLBRECQLMAPTKDM4E | |
| SCHEMBL7720119 | 0.87 | MAPT (0.53) | SMN1; SMN2POLBAPEX1RECQLCTDSP1 | |
| SCHEMBL7723670 | 0.81 | MAPT (0.63) | SMN1; SMN2POLBAPEX1RECQLCTDSP1 | |
| SCHEMBL7724736 | 0.80 | KDM4E (0.50) | SMN1; SMN2POLBMAPTKDM4EALDH1A1 | |
| SCHEMBL7724741 | 0.80 | KDM4E (0.50) | SMN1; SMN2POLBMAPTKDM4EALDH1A1 | |
| SCHEMBL7724970 | 0.80 | CRHR1 (0.49) | SMN1; SMN2POLBAPEX1RECQLCTDSP1 | |
| SCHEMBL7730097 | 0.79 | LMNA (0.48) | SMN1; SMN2POLBAPEX1RECQLCTDSP1 | |
| SCHEMBL7723465 | 0.78 | PLA2G2A (0.46) | SMN1; SMN2POLBAPEX1RECQLCTDSP1 | |
| SCHEMBL7723464 | 0.78 | PLA2G2A (0.46) | SMN1; SMN2POLBAPEX1RECQLCTDSP1 | |
| SCHEMBL7723462 | 0.77 | PDE4A (0.54) | SMN1; SMN2POLBAPEX1RECQLCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |