SCHEMBL7720311

SCHEMBL7720311

Cc1c(C)c(C)c2cc(C#N)ccc2c1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.48
ALDH1A1 P00352 1/20 0.48
CHUK O15111 1/20 0.41
MAOB P27338 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CA2 P00918 3/20 0.38
CA1 P00915 2/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
CA12 O43570 1/20 0.37
CA3 P07451 1/20 0.37
CA6 P23280 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
AR P10275 1/20 0.37
KDM1A O60341 1/20 0.36
IMPDH2 P12268 1/20 0.36
IMPDH1 P20839 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13074276 0.79 CA2 (0.43) CYP2A6ALDH1A1CHUKL3MBTL1MEN1
SCHEMBL806521 0.77 CYP11B1 (0.43) CYP2A6ALDH1A1CHUKL3MBTL1MEN1
SCHEMBL30506249 0.76 ALDH1A1 (0.43) CYP2A6ALDH1A1CHUKL3MBTL1MEN1
SCHEMBL20116697 0.76 ALDH1A1 (0.43) CYP2A6ALDH1A1CHUKL3MBTL1MEN1
SCHEMBL11986226 0.74 GRM2 (0.38) CYP2A6ALDH1A1KMT2ACA2CA1
SCHEMBL149913 0.73 MDM4 (0.41) CYP2A6ALDH1A1CHUKL3MBTL1MEN1
SCHEMBL29540307 0.73 MDM4 (0.41) CYP2A6ALDH1A1CHUKL3MBTL1MEN1
SCHEMBL18934329 0.73 CA1 (0.53) CYP2A6ALDH1A1MAOBMEN1KMT2A
SCHEMBL18030923 0.73 L3MBTL1 (0.41) CYP2A6ALDH1A1L3MBTL1MEN1KMT2A
SCHEMBL6363289 0.73 EGFR (0.46) CYP2A6ALDH1A1L3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6358995-B1 AGONIST FOR RETINOIC ACID RECEPTORS; CAN BE SUBSTITUTED FOR RETINOIC ACID AS PREVENTIVE AND THERAPEUTIC DRUGS FOR VARIOUS DISEASES OR CANCERS, SUCH AS ACUTE PROMYELOCYTIC LEUKEMIA. EISAI CO., LTD. (JP) 2002-03-19 US disclosed
US-6121309-A SUCH AS 4-(2-(5-(7-FLUORO-4-TRIFLUOROMETHYLBENZOFURAN-2-YL)PYRROLYL)) BENZOIC ACID; RETINOIC ACID RECEPTOR AGONISM EISAI CO., LTD. (JP) 2000-09-19 US disclosed
US-6110959-A A RETINOIC ACID RECEPTOR AGONIST EISAI CO., LTD. (JP) 2000-08-29 US disclosed
EP-0889032-A1 FUSED-RING CARBOXYLIC ACID DERIVATIVES Eisai Co., Ltd. (JP) 1999-01-07 EP disclosed