Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.51 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791987 | 0.93 | GAA (0.47) | GAALMNACACNA1GREV1HTR1A | |
| SCHEMBL7720501 | 0.85 | GAA (0.47) | GAALMNARXFP1CACNA1GREV1 | |
| SCHEMBL6795176 | 0.85 | PKM (0.52) | CACNA1GMAPTHTR7SMN1; SMN2HTR1A | |
| SCHEMBL6789349 | 0.85 | HTR7 (0.45) | HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL6788271 | 0.85 | MTTP (0.58) | HTR7 | |
| SCHEMBL6792842 | 0.83 | DRD3 (0.46) | HTR7HTR2AHTR2C | |
| SCHEMBL6794501 | 0.83 | HTR1A (0.49) | GAALMNAMAPTHTR7SMN1; SMN2 | |
| SCHEMBL6792149 | 0.83 | MTTP (0.59) | — | |
| SCHEMBL6797449 | 0.82 | HTR2A (0.52) | HTR7HTR1AHTR2AHTR2C | |
| SCHEMBL6789329 | 0.82 | HTR1A (0.44) | HTR7HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818644-B1 | FLUORENE-9-CARBOXYLIC AMIDES; INHIBITORS OF MICROSOMAL TRIGLYSERIDE-TRANSFER PROTEIN (MTP); ANTILIPEMIC AGENTS; ATHEROSCLEROSIS, DIABETES, EATING DISORDERS, AND PANCREATITIS | BOEHRINGER INGELHEIM PHARM GMBH & CO, KG (DE) | 2004-11-16 | — | — | US | disclosed |