Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 8/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723488 | 0.84 | TDP1 (0.47) | TDP1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7721075 | 0.84 | AOC3 (0.40) | TBXAS1TDP1NPC1RAB9ASLC6A1 | |
| SCHEMBL8328095 | 0.78 | MEN1 (0.42) | TDP1NPC1RAB9AMAPTSLC6A1 | |
| SCHEMBL24763738 | 0.78 | CHRM3 (0.41) | TBXAS1TDP1SLC6A1SLC6A11 | |
| SCHEMBL8330752 | 0.76 | SLC6A1 (0.37) | TDP1NPC1RAB9AMAPTSLC6A1 | |
| SCHEMBL20742091 | 0.75 | ADRB2 (0.52) | MAPTKMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL20742093 | 0.75 | ADRB2 (0.52) | MAPTKMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL30866255 | 0.75 | PLA2G2A (0.48) | TBXAS1TDP1SLC6A1 | |
| SCHEMBL30866257 | 0.75 | PLA2G2A (0.48) | TBXAS1TDP1SLC6A1 | |
| SCHEMBL25764010 | 0.73 | PLA2G2A (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739351-B1 | MONOMERIC DIOLS AND PHOSPHATE LINKED OLIGOMERS FORMED THEREFROM | ISIS PHARMACEUTICALS INC (US) | 2002-04-10 | — | — | EP | disclosed |
| US-5886177-A | ETHYLENE GLYCOL MONOMERS JOINED VIA STANDARD PHOSPHATE LINKAGES INCLUDING PHOSPHOROTHIOATE, PHOSPHODIESTER, AND PHOSPHORAMIDATE LINKAGES; USEFUL FUNCTIONAL GROUPS INCLUDE NUCLEOBASES AS WELL AS POLAR GROUPS, HYDROPHOBIC GROUPS | ISIS PHARMACEUTICALS, INC. (US) | 1999-03-23 | — | — | US | disclosed |