Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | GNRHR | P30968 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7721157 | 0.88 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2TP53HSD17B10NPC1 | |
| SCHEMBL7726932 | 0.81 | HSD17B10 (0.53) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL7721559 | 0.81 | SMN1; SMN2 (0.53) | LMNASMN1; SMN2TP53HSD17B10NPC1 | |
| SCHEMBL7721154 | 0.81 | ALDH1A1 (0.50) | LMNAMAPTSMN1; SMN2NPC1MEN1 | |
| SCHEMBL12500188 | 0.78 | POLB (0.69) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL12203800 | 0.77 | MAPT (0.65) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL6280071 | 0.76 | NPC1 (0.59) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL10869503 | 0.75 | LMNA (0.52) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL7721161 | 0.75 | PDE10A (0.54) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL7721500 | 0.75 | POLB (0.63) | LMNAMAPTSMN1; SMN2TP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875765-B2 | Arylsulfonamide ethers, and methods of use thereof | WARNER-LAMBERT COMPANY (US) | 2005-04-05 | — | — | US | disclosed |