SCHEMBL7723241

SCHEMBL7723241

CC(C)(C)OC(=O)NCCC[C@@H](N)C(=O)N(C(=O)OC(C)(C)C)[C@H](CCc1ccccc1)c1nc(C(=O)Nc2cnc3ccccc3c2)co1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 3/20 0.40
HDAC1 Q13547 3/20 0.40
HDAC3 O15379 2/20 0.40
HDAC7 Q8WUI4 2/20 0.40
HDAC2 Q92769 2/20 0.40
HDAC10 Q969S8 2/20 0.40
HDAC11 Q96DB2 2/20 0.40
HDAC8 Q9BY41 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
HDAC9 Q9UKV0 2/20 0.40
HDAC5 Q9UQL6 2/20 0.40
SCN9A Q15858 1/20 0.38
TRPV1 Q8NER1 8/20 0.38
RAB9A P51151 3/20 0.37
NPC1 O15118 2/20 0.37
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7723264 0.91 SCD (0.35) MAPTSCDMMP1MMP3MMP9
SCHEMBL7723327 0.83 MAPT (0.44) MAPTL3MBTL1MEN1KMT2AMMP1
SCHEMBL7730530 0.82 MAPT (0.38) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL7733653 0.80 MAPT (0.40) MAPTL3MBTL1MEN1KMT2A
SCHEMBL7731132 0.79 HDAC4 (0.43) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL7732103 0.75 RAB9A (0.53) HDAC4HDAC1HDAC3HDAC7HDAC2
Trifluoroacetic Acid SCHEMBL7735917 0.73 RAB9A (0.48) HDAC4SCN9ATRPV1RAB9ANPC1
SCHEMBL7735983 0.72 RAB9A (0.44) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL12890809 0.72 HDAC1 (0.68) HDAC4HDAC1HDAC3HDAC7HDAC2
SCHEMBL7731104 0.71 MAPT (0.39) MAPTMEN1KMT2AMMP1MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6436980-B1 TRANSPORT PROTEIN SUPPRESSORS; MICROBIOCIDES ESSENTIAL THERAPEUTICS, INC. 2002-08-20 US disclosed
US-6204279-B1 SECONDARY AMIDE CONTAINING BENZOXAZOLE DERIVATIVES MICROCIDE PHARMACEUTICALS, INC. 2001-03-20 US disclosed