Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30132805 | 0.99 | MAPT (0.52) | MAPTMAPK1RAB9ANPC1NFKB1 | |
| SCHEMBL5787352 | 0.99 | MAPT (0.52) | MAPTMAPK1RAB9ANPC1NFKB1 | |
| SCHEMBL2107427 | 0.86 | MAPT (0.51) | MAPTMAPK1RAB9ANPC1NFKB1 | |
| SCHEMBL15709862 | 0.85 | LMNA (0.61) | MAPTMAPK1RAB9ANPC1NFKB1 | |
| SCHEMBL27856348 | 0.84 | MAPT (0.52) | MAPTMAPK1RAB9ANPC1NFKB1 | |
| Ethyl Acetate SCHEMBL29391722 | 0.83 | RAB9A (0.48) | MAPTMAPK1RAB9ANPC1NFKB1 | |
| SCHEMBL3796044 | 0.81 | MAPK1 (0.61) | MAPTMAPK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL31031180 | 0.81 | MAPK1 (0.61) | MAPTMAPK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL31213829 | 0.80 | ALDH1A1 (0.53) | MAPTMAPK1RAB9ANPC1NFKB1 | |
| SCHEMBL27985684 | 0.80 | ALDH1A1 (0.53) | MAPTMAPK1RAB9ANPC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |