Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723465 | 1.00 | PLA2G2A (0.46) | PLA2G2ADHODHRAB9AKDM4EAKR1B10 | |
| SCHEMBL7726091 | 0.92 | PLA2G2A (0.52) | PLA2G2ARAB9AKDM4ELMNARXFP1 | |
| SCHEMBL7726088 | 0.92 | PLA2G2A (0.52) | PLA2G2ARAB9AKDM4ELMNARXFP1 | |
| SCHEMBL7723443 | 0.89 | MAPT (0.45) | PLA2G2ADHODHRAB9AKDM4ENPC1 | |
| SCHEMBL7723444 | 0.89 | MAPT (0.45) | PLA2G2ADHODHRAB9AKDM4ENPC1 | |
| SCHEMBL7724793 | 0.83 | LMNA (0.42) | PLA2G2ARAB9AKDM4ENPC1MAPT | |
| SCHEMBL7724798 | 0.83 | LMNA (0.42) | PLA2G2ARAB9AKDM4ENPC1MAPT | |
| SCHEMBL7724741 | 0.80 | KDM4E (0.50) | PLA2G2ADHODHKDM4EMAPTALDH1A1 | |
| SCHEMBL7724736 | 0.80 | KDM4E (0.50) | PLA2G2ADHODHKDM4EMAPTALDH1A1 | |
| SCHEMBL7723615 | 0.78 | SMN1; SMN2 (0.44) | RAB9AKDM4ENPC1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |