Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094890 | 0.91 | SMN1; SMN2 (0.36) | BCHENAMPTSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL5257422 | 0.81 | QPCT (0.45) | BCHENAMPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL2482514 | 0.81 | THRB (0.37) | SMN1; SMN2ALDH1A1TSHRGAATDP1 | |
| SCHEMBL15570675 | 0.80 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1KDM4ETDP1 | |
| SCHEMBL17726997 | 0.80 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1TSHRGAAMAPT | |
| SCHEMBL693414 | 0.80 | DUT (0.33) | ALDH1A1GAA | |
| SCHEMBL8631416 | 0.80 | L3MBTL1 (0.36) | SMN1; SMN2ALDH1A1HSD17B10MAPTNPC1 | |
| SCHEMBL11121639 | 0.80 | L3MBTL1 (0.36) | SMN1; SMN2ALDH1A1HSD17B10MAPTNPC1 | |
| SCHEMBL12031906 | 0.79 | L3MBTL1 (0.33) | SMN1; SMN2ALDH1A1TSHRGAATDP1 | |
| SCHEMBL18034386 | 0.79 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1TSHRGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403805-B1 | SUCH AS 1-((1-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL) CYCLOPROPYL)METHYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE FOR ALLERGIES, ATOPIC AND INFLAMMATORY DISEASES WHEREIN ACTIVITY OF PHOSPHODIESTERASE IS ALTERED | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-06-11 | — | — | US | disclosed |