Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | YAP1 | P46937 | 3/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7722094 | 0.83 | GPR119 (0.36) | USP30GPR119 | |
| SCHEMBL7722244 | 0.83 | GPR119 (0.36) | USP30GPR119 | |
| SCHEMBL7727252 | 0.82 | KDM4E (0.46) | MCL1GHSR | |
| SCHEMBL7727837 | 0.79 | SIGMAR1 (0.43) | HSD11B1 | |
| SCHEMBL7730641 | 0.78 | NPBWR1 (0.39) | GPR119 | |
| SCHEMBL76105 | 0.77 | YAP1 (0.60) | YAP1PRMT5USP30GPR119 | |
| SCHEMBL7728833 | 0.77 | SIRT2 (0.47) | GHSR | |
| SCHEMBL7730983 | 0.77 | MCL1 (0.45) | MCL1YAP1PRMT5GHSR | |
| SCHEMBL7730981 | 0.77 | MCL1 (0.45) | MCL1YAP1PRMT5GHSR | |
| SCHEMBL7730972 | 0.77 | MCL1 (0.45) | MCL1YAP1PRMT5GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2000001714-A1 | EFFLUX PUMP INHIBITORS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |