SCHEMBL7729709

SCHEMBL7729709

COC(=O)C(Cl)Cc1cc(N2C(=O)c3ccccc3C2=O)c(F)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 12/20 0.39
GRM4 Q14833 5/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPT P10636 1/20 0.37
LMNA P02545 1/20 0.37
TP53 P04637 1/20 0.37
CASP3 P42574 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
GRM7 Q14831 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7729726 0.91 PPOX (0.42) GRM1GRM4MEN1KMT2AMAPT
SCHEMBL7733763 0.90 ALDH1A1 (0.39) GRM1GRM4MEN1KMT2AMAPT
SCHEMBL7734263 0.86 CYP3A4 (0.39) GRM1GRM4MEN1KMT2AGRM7
SCHEMBL7734095 0.86 ALDH1A1 (0.39) GRM1GRM4MEN1KMT2ATP53
SCHEMBL7729011 0.83 KMT2A (0.38) GRM1GRM4MEN1KMT2AGRM7
SCHEMBL7734418 0.82 GRM1 (0.44) GRM1GRM4MEN1KMT2AMAPT
SCHEMBL7767630 0.75 PPOX (0.46) GRM4GRM7
SCHEMBL8020623 0.74 KMT2A (0.41) GRM1MEN1KMT2AMAPT
SCHEMBL5388798 0.72 PPOX (0.56) MEN1KMT2AMAPTLMNATP53
SCHEMBL6727419 0.72 GPR139 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6365753-B1 EXCELLENT PREFERENTIAL EFFECTS ON WEEDS; GRASSES; NONPHYTOTOXIC TO CROPS E.G. WHEAT; BARLEY; CORN MITSUBISHI CHEMICAL CORPORATION (JP) 2002-04-02 US disclosed