SCHEMBL7734263

SCHEMBL7734263

O=C(Cl)C(Cl)Cc1cc(N2C(=O)c3ccccc3C2=O)c(F)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.39
NFKB1 P19838 1/20 0.39
PMP22 Q01453 1/20 0.39
GRM1 Q13255 5/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
GRM4 Q14833 4/20 0.36
GRM7 Q14831 1/20 0.35
P2RX7 Q99572 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7734095 0.91 ALDH1A1 (0.39) CYP3A4NFKB1PMP22GRM1MEN1
SCHEMBL7729726 0.86 PPOX (0.42) GRM1MEN1KMT2AGRM4
SCHEMBL7729709 0.86 GRM1 (0.39) GRM1MEN1KMT2AGRM4GRM7
SCHEMBL7733763 0.85 ALDH1A1 (0.39) CYP3A4NFKB1PMP22GRM1MEN1
SCHEMBL7729011 0.83 KMT2A (0.38) CYP3A4NFKB1PMP22GRM1MEN1
SCHEMBL7734418 0.77 GRM1 (0.44) GRM1MEN1KMT2AESR1ESR2
SCHEMBL8020623 0.75 KMT2A (0.41) CYP3A4NFKB1PMP22GRM1MEN1
SCHEMBL8020629 0.74 CYP3A4 (0.39) CYP3A4NFKB1PMP22GRM1MEN1
SCHEMBL5388823 0.74 ESR1 (0.49) CYP3A4NFKB1PMP22GRM1MEN1
SCHEMBL30566764 0.74 ESR1 (0.49) CYP3A4NFKB1PMP22GRM1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6365753-B1 EXCELLENT PREFERENTIAL EFFECTS ON WEEDS; GRASSES; NONPHYTOTOXIC TO CROPS E.G. WHEAT; BARLEY; CORN MITSUBISHI CHEMICAL CORPORATION (JP) 2002-04-02 US disclosed
EP-1097923-A1 PHTHALIMIDES AND HERBICIDE CONTAINING THE SAME AS ACTIVE COMPONENT MITSUBISHI CHEMICAL CORPORATION (JP) 2001-05-09 EP disclosed