SCHEMBL7729779

SCHEMBL7729779

C#CC(O)(c1ccc(-c2ccccc2)cc1)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.50
KIF11 P52732 1/20 0.46
PTPN5 P54829 1/20 0.42
MMP3 P08254 1/20 0.41
BCL2L1 Q07817 1/20 0.41
ALDH1A1 P00352 2/20 0.39
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
MGLL Q99685 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CTDSP1 Q9GZU7 1/20 0.36
CYP3A4 P08684 2/20 0.36
MAPK1 P28482 1/20 0.36
CYP17A1 P05093 1/20 0.36
CYP1A2 P05177 1/20 0.36
TAAR1 Q96RJ0 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
ALOX5 P09917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7734271 0.98 CYP2C9 (0.48) CYP2C9KIF11PTPN5MMP3BCL2L1
SCHEMBL10102374 0.91 CYP2C9 (0.43) CYP2C9KIF11PTPN5ALDH1A1NPC1
SCHEMBL11479898 0.87 KCNN4 (0.43) CYP2C9KIF11PTPN5BCL2L1ALDH1A1
SCHEMBL11479828 0.87 ALDH1A1 (0.48) CYP2C9KIF11PTPN5MMP3ALDH1A1
SCHEMBL11492725 0.87 CYP1A2 (0.48) CYP2C9KIF11CYP3A4MAPK1CYP1A2
SCHEMBL362964 0.86 TSHR (0.43) CYP2C9ALDH1A1CYP3A4CYP1A2
SCHEMBL26513230 0.85 L3MBTL1 (0.41) CYP2C9KIF11ALDH1A1NPC1RAB9A
SCHEMBL11245549 0.83 CYP19A1 (0.38) CYP2C9KIF11CYP1A2TAAR1ALOX5
SCHEMBL26629595 0.81 ESR1 (0.52) KIF11MMP3BCL2L1ALDH1A1CA1
SCHEMBL11481112 0.80 CYP2A6 (0.52) NPC1RAB9ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6337409-B1 3,3-DISUBSTITUTED NAPHTHOPYRAN; COLOR RESPONSE UPON ULTRAVIOLET LIGHT EXPOSURE EXTENDS TO ORANGE, REDDISH-ORANGE OR PURPLE; BATHYCHROMIC SHIFT OF MAXIMUM ACTIVATED WAVELENGTH; PLASTIC OPHTHALMIC LENSES VISION-EASE LENS, INC. 2002-01-08 US disclosed
US-5759450-A OPTICAL ELEMENTS VISION-EASE LENS, INC. (US) 1998-06-02 US disclosed
WO-1997006455-A1 PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS BMC INDUSTRIES, INC. (US) 1997-02-20 WO disclosed
US-5531935-A PHOTOCHROMIC ARTICLES; THE NAPHTHOPYRANS HAVE A SUBSTITUTED PHENYL OR SUBSTITUTED NAPHTHYL SUBSTITUENT, AT LEAST ONE OF THE SUBSTITUTIONS BEING PHENYL OR NAPHTHYL BMC INDUSTRIES, INC. (US) 1996-07-02 US disclosed