Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720252 | 0.89 | ALDH1A1 (0.47) | KDM4EALDH1A1GLAHPGDHTT | |
| SCHEMBL7723580 | 0.89 | KDM4E (0.56) | PLA2G2AKDM4EALDH1A1GLAHPGD | |
| SCHEMBL7720344 | 0.86 | PLA2G2A (0.51) | PLA2G2AKDM4EALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7723532 | 0.84 | GABRG2 (0.49) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7720271 | 0.81 | MAPT (0.64) | PLA2G2ATDP1GABRG2GABRB3GABRA3 | |
| SCHEMBL7723102 | 0.79 | PLA2G2A (0.54) | PLA2G2AKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL7724790 | 0.79 | ALDH1A1 (0.55) | KDM4EALDH1A1GLAHPGDHTT | |
| SCHEMBL7720244 | 0.79 | MAPT (0.51) | PLA2G2AKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7724767 | 0.78 | NPC1 (0.54) | PLA2G2AALDH1A1HTTCYP1A2CYP2D6 | |
| SCHEMBL7726371 | 0.77 | PLA2G2A (0.48) | PLA2G2AKDM4EALDH1A1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |