Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7720189 | 0.86 | TACR3 (0.58) | KMT2AMEN1GSK3BALDH1A1HTT | |
| SCHEMBL7723633 | 0.85 | ADORA2A (0.53) | ADORA2AADORA1KMT2AMEN1GSK3B | |
| SCHEMBL7730164 | 0.83 | ADORA2A (0.54) | ADORA2AADORA1KMT2AMEN1GSK3B | |
| SCHEMBL7723678 | 0.83 | ADORA2A (0.51) | ADORA2AADORA1KMT2AMEN1GSK3B | |
| SCHEMBL7723469 | 0.81 | JAK2 (0.52) | HPGDALDH1A1KDM4ELMNAHTT | |
| SCHEMBL7723102 | 0.76 | PLA2G2A (0.54) | KMT2AMEN1HPGDALDH1A1KDM4E | |
| SCHEMBL23495338 | 0.75 | POLB (0.67) | KMT2AMEN1HPGDALDH1A1KDM4E | |
| SCHEMBL29436204 | 0.75 | POLB (0.67) | KMT2AMEN1HPGDALDH1A1KDM4E | |
| SCHEMBL6450710 | 0.74 | TACR3 (0.76) | ADORA2AADORA1KMT2AMEN1HPGD | |
| SCHEMBL7720232 | 0.72 | MAPT (0.54) | KMT2AMEN1HPGDALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |