Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29436204 | 0.84 | POLB (0.67) | KMT2AMEN1KDM4EUSP2ALOX15 | |
| SCHEMBL23495338 | 0.84 | POLB (0.67) | KMT2AMEN1KDM4EUSP2ALOX15 | |
| SCHEMBL7730172 | 0.84 | LMNA (0.51) | KMT2AMEN1RXFP1TDP1KDM4E | |
| SCHEMBL7723633 | 0.83 | ADORA2A (0.53) | ADORA2AADORA1KMT2AMEN1KDM4E | |
| SCHEMBL7730191 | 0.83 | ADORA2A (0.59) | ADORA2AADORA1KMT2AMEN1KDM4E | |
| SCHEMBL7724650 | 0.82 | RAB9A (0.49) | KMT2ATDP1KDM4EHSD17B10POLB | |
| SCHEMBL7723678 | 0.82 | ADORA2A (0.51) | ADORA2AADORA1KMT2AMEN1KDM4E | |
| SCHEMBL7725155 | 0.78 | JAK2 (0.47) | KMT2ATDP1KDM4EALDH1A1MAPT | |
| SCHEMBL7720270 | 0.77 | MAPT (0.59) | ADORA2AKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL7723640 | 0.77 | ALDH1A1 (0.52) | KMT2AMEN1TDP1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |