Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | UBE2I | P63279 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730191 | 0.86 | ADORA2A (0.59) | TP53MAPTNPC1RAB9AHTT | |
| SCHEMBL7723469 | 0.84 | JAK2 (0.52) | MAPTNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7724827 | 0.83 | TACR3 (0.52) | TACR3HDAC1TP53MAPTNPC1 | |
| SCHEMBL7724857 | 0.82 | L3MBTL1 (0.50) | TACR3HDAC1TP53MAPTNPC1 | |
| SCHEMBL7723102 | 0.79 | PLA2G2A (0.54) | MAPTNPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL7720270 | 0.79 | MAPT (0.59) | HDAC1MAPTNPC1RAB9AHTT | |
| SCHEMBL7720232 | 0.75 | MAPT (0.54) | MAPTNPC1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL7720271 | 0.74 | MAPT (0.64) | HDAC1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7723670 | 0.73 | MAPT (0.63) | HDAC1MAPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL23495195 | 0.73 | TP53 (0.72) | TP53MAPTHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |