Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7063803 | 0.87 | ALDH1A1 (0.39) | KDM4EMAPTKMT2ACASP3SENP8 | |
| Hydrochloric Acid SCHEMBL3669142 | 0.84 | SMARCA2 (0.35) | KDM4EMAPTKMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7734556 | 0.83 | KDM4E (0.33) | KDM4EMAPTKMT2ACASP3SENP8 | |
| Hydrochloric Acid SCHEMBL7728448 | 0.83 | KDM4E (0.33) | KDM4EMAPTKMT2ACASP3SENP8 | |
| Hydrochloric Acid SCHEMBL6902711 | 0.81 | MAOA (0.32) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6902210 | 0.81 | ALDH1A1 (0.36) | KDM4EMAPTKMT2ANPC1RAB9A | |
| SCHEMBL7061941 | 0.80 | KDM4E (0.32) | KDM4EMAPTKMT2ACASP3SENP8 | |
| SCHEMBL7728456 | 0.80 | KDM4E (0.32) | KDM4EMAPTKMT2ACASP3SENP8 | |
| SCHEMBL7734561 | 0.80 | ALDH1A1 (0.33) | KDM4EMAPTKMT2ACASP3SENP8 | |
| Hydrochloric Acid SCHEMBL7732776 | 0.79 | ADORA2A (0.34) | KDM4EMAPTKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6635733-B2 | Coordination catalyst; radiation transparent, elasticity | CHISSO CORPORATION (JP) | 2003-10-21 | — | — | US | disclosed |
| US-6479646-B1 | Metallocene compounds having indenyl ligand and catalysts for olefin polymerization containing the same | CHISSO CORPORATION (JP) | 2002-11-12 | — | — | US | disclosed |
| US-20020002261-A1 | Elastomeric polypropylene | JNC PETROCHEMICAL CORPORATION (JP) | 2002-01-03 | — | — | US | disclosed |
| US-20010031834-A1 | Using coordination catalyst; flexibility, elasticity; molding materials | CHISSO CORPORATION | 2001-10-18 | — | — | US | disclosed |