Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7739291 | 1.00 | HSD11B1 (0.36) | HSD11B1EPHX1EPHX2ALDH1A1KMT2A | |
| SCHEMBL7739298 | 0.91 | HSD11B1 (0.33) | HSD11B1EPHX1EPHX2ALDH1A1KMT2A | |
| Bicarbonate SCHEMBL7733359 | 0.69 | THRB (0.33) | HSD11B1EPHX1EPHX2ALDH1A1NPC1 | |
| Bicarbonate SCHEMBL2521295 | 0.69 | THRB (0.33) | HSD11B1EPHX1EPHX2ALDH1A1NPC1 | |
| Bicarbonate SCHEMBL7739518 | 0.69 | THRB (0.33) | HSD11B1EPHX1EPHX2ALDH1A1NPC1 | |
| SCHEMBL6235075 | 0.68 | HSD11B1 (0.34) | HSD11B1EPHX1EPHX2 | |
| SCHEMBL1088728 | 0.68 | THRB (0.35) | HSD11B1EPHX1EPHX2ALDH1A1NPC1 | |
| Bicarbonate SCHEMBL7732730 | 0.68 | EPHX1 (0.35) | HSD11B1EPHX1EPHX2ALDH1A1KMT2A | |
| SCHEMBL183883 | 0.66 | LMNA (0.33) | HSD11B1SIGMAR1THRB | |
| SCHEMBL5969631 | 0.64 | EPHX1 (0.35) | HSD11B1EPHX1EPHX2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410748-B1 | Alicycli c group-containing monomer | KABUSHIKI KAISHA TOSHIBA (JP) | 2002-06-25 | — | — | US | disclosed |
| US-6291129-B1 | LIGHT SENSITIVE ELEMENT WITH UNSATURATED POLYMERS | KABUSHIKI KAISHA TOSHIBA (JP) | 2001-09-18 | — | — | US | disclosed |