SCHEMBL7733325

SCHEMBL7733325

C=C(NC(C)=O)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.57
SMN1; SMN2 Q16637 4/20 0.57
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
CTDSP1 Q9GZU7 1/20 0.48
L3MBTL1 Q9Y468 2/20 0.47
ALDH1A1 P00352 5/20 0.47
POLB P06746 1/20 0.47
HPGD P15428 2/20 0.44
ERCC5 P28715 1/20 0.44
FEN1 P39748 1/20 0.44
HAO1 Q9UJM8 1/20 0.44
LMNA P02545 1/20 0.44
GAA P10253 1/20 0.44
ALOX12 P18054 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
KDM4E B2RXH2 3/20 0.44
HDAC1 Q13547 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL979427 0.88 CES1 (0.46) MAPTSMN1; SMN2NPC1RAB9AL3MBTL1
SCHEMBL19435693 0.80 MAPT (0.45) MAPTSMN1; SMN2NPC1RAB9AL3MBTL1
SCHEMBL14755266 0.80 SMN1; SMN2 (0.46) MAPTSMN1; SMN2NPC1RAB9ACTDSP1
Biphenyl SCHEMBL28188851 0.80 SMN1; SMN2 (0.56) MAPTSMN1; SMN2NPC1RAB9ACTDSP1
SCHEMBL7733506 0.79 ALDH1A1 (0.48) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL19724896 0.79 CA1 (0.47) MAPTNPC1RAB9AALDH1A1HPGD
SCHEMBL14537184 0.77 ALDH1A1 (0.53) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL27568390 0.77 CES2 (0.46) SMN1; SMN2L3MBTL1ALDH1A1POLBMEN1
SCHEMBL6294231 0.77 EPHX1 (0.49) MAPTSMN1; SMN2NPC1RAB9AL3MBTL1
SCHEMBL19435712 0.77 TPMT (0.45) SMN1; SMN2ALDH1A1LMNAGAAGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113480533-B Preparation method of 3, 4-pyridine diimides derivatives 赣南师范大学 2022-08-02 CN disclosed
CN-113307766-A Method for synthesizing pyridine compound by using microchannel reaction device 南京先进生物材料与过程装备研究院有限公司 2021-08-27 CN disclosed
US-6399787-B1 TRANSITION METAL COMPLEX PENN STATE RESEARCH FOUNDATION 2002-06-04 US disclosed
WO-1999059721-A1 CATALYTIC ASYMMETRIC HYDROGENATION, HYDROFORMYLATION, AND HYDROVINYLATION VIA TRANSITION METAL CATALYSTS WITH PHOSPHINES AND PHOSPHITES THE PENN STATE RESEARCH FOUNDATION (US) 1999-11-25 WO disclosed