SCHEMBL7733997

SCHEMBL7733997

O=C(Cl)c1ccc(C(F)(F)F)cc1F.O=C(Cl)c1cccc(C(F)(F)F)c1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.46
ALDH1A1 P00352 2/20 0.44
ALOX15 P16050 1/20 0.44
GAA P10253 1/20 0.43
TRPV1 Q8NER1 2/20 0.40
NTRK1 P04629 1/20 0.40
KAT6A Q92794 2/20 0.40
RXFP1 Q9HBX9 2/20 0.39
CTSS P25774 1/20 0.39
MRGPRX4 Q96LA9 1/20 0.39
KDM4E B2RXH2 2/20 0.38
HTT P42858 1/20 0.38
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38
TAS1R2 Q8TE23 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
GPR27 Q9NS67 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL496324 0.85 GAA (0.54) CES2ALDH1A1ALOX15GAATRPV1
SCHEMBL283643 0.85 KAT6A (0.49) CES2ALDH1A1ALOX15GAAKAT6A
SCHEMBL8674347 0.79 GAA (0.49) CES2ALDH1A1ALOX15GAATRPV1
SCHEMBL8675845 0.75 CES2 (0.58) CES2ALDH1A1ALOX15GAATRPV1
SCHEMBL937022 0.75 CES2 (0.72) CES2ALDH1A1GAAKDM4EGPR27
SCHEMBL30518051 0.75 CES2 (0.72) CES2ALDH1A1GAAKDM4EGPR27
SCHEMBL8675691 0.74 ALDH1A1 (0.49) CES2ALDH1A1ALOX15GAAKAT6A
SCHEMBL13389880 0.73 ALDH1A1 (0.41) CES2ALDH1A1ALOX15GAAKAT6A
SCHEMBL17732182 0.73 KIF11 (0.54) CES2ALDH1A1ALOX15GAATRPV1
SCHEMBL15918189 0.72 ALDH1A1 (0.46) CES2ALDH1A1ALOX15GAANTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015479-A4 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR LILLY CO ELI (US) 2002-07-24 EP disclosed
EP-1015479-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 2000-07-05 EP disclosed
WO-1998046631-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC MACROCYCLES AND PROCESSES THEREFOR ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed