Sugi Predict

Sugi Predict / Compounds / SCHEMBL283643

SCHEMBL283643

SCHEMBL283643

O=C(Cl)c1cccc(C(F)(F)F)c1F

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KAT6A Q92794 2/20 0.49
▸ ALDH1A1 P00352 1/20 0.48
▸ ALOX15 P16050 1/20 0.48
▸ CTSS P25774 2/20 0.48
▸ TAS1R3 Q7RTX0 1/20 0.47
▸ TAS1R1 Q7RTX1 1/20 0.47
▸ TAS1R2 Q8TE23 1/20 0.47
▸ LMNA P02545 1/20 0.46
▸ GAA P10253 1/20 0.46
▸ P2RX7 Q99572 4/20 0.43
▸ HDAC8 Q9BY41 1/20 0.43
▸ GPBAR1 Q8TDU6 1/20 0.40
▸ TAS2R14 Q9NYV8 2/20 0.40
▸ CES2 O00748 1/20 0.39
▸ BCHE P06276 1/20 0.39
▸ CES1 P23141 1/20 0.39
▸ CNR1 P21554 2/20 0.39
▸ CNR2 P34972 2/20 0.39
▸ NOTUM Q6P988 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7733997 0.85 CES2 (0.46) KAT6AALDH1A1ALOX15CTSSTAS1R3
SCHEMBL28188796 0.84 KAT6A (0.51) KAT6ACTSSTAS1R3TAS1R1TAS1R2
SCHEMBL18131351 0.83 ALDH1A1 (0.47) KAT6AALDH1A1ALOX15CTSSTAS1R3
SCHEMBL9560994 0.82 KAT6A (0.50) KAT6ACTSSTAS1R3TAS1R1TAS1R2
SCHEMBL13389880 0.82 ALDH1A1 (0.41) KAT6AALDH1A1ALOX15CTSSTAS1R3
SCHEMBL398909 0.82 KAT6A (0.54) KAT6AALDH1A1ALOX15CTSSTAS1R3
SCHEMBL24201 0.82 LMNA (0.60) ALDH1A1ALOX15LMNAGAATAS2R14
SCHEMBL19185970 0.81 ALDH1A1 (0.62) KAT6AALDH1A1ALOX15GAACES2
SCHEMBL20560629 0.81 KAT6A (0.42) KAT6ACTSSTAS1R3TAS1R1TAS1R2
SCHEMBL477444 0.81 KAT6A (0.49) KAT6AALDH1A1CTSSTAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 294 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108409686-A A kind of drug and preparation method thereof can be used for preparing treatment respiratory syncytial virus infection 青岛康庆和医药科技有限责任公司 2018-08-17 — — CN claimed
US-12338243-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-06-24 — — US disclosed
CN-120152713-A Tricyclic aryl derivatives and compositions and methods thereof 昂胜医疗科技公司 2025-06-13 — — CN disclosed
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 — — US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-11708344-B2 Flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease HOFFMANN-LA ROCHE INC. (US) 2023-07-25 — — US disclosed
US-20230074887-A1 FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE HOFFMANN-LA ROCHE INC. (US) 2023-03-09 — — US disclosed
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 — — EP disclosed
US-5942387-A Combinatorial process for preparing substituted thiophene libraries ELI LILLY AND COMPANY (US) 1999-08-24 — — US disclosed
CN-1214632-A Remedies or preventives for AIDS SANKYO CO (JP) 1999-04-21 — — CN disclosed
EP-0880558-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED INDANE LIBRARIES ELI LILLY AND COMPANY (US) 1998-12-02 — — EP disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 — — WO disclosed
WO-1998008839-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED THIOPHENE LIBRARIES ELI LILLY AND COMPANY (US) 1998-03-05 — — WO disclosed
WO-1998008813-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED PYRROLIDINE LIBRARIES ELI LILLY AND COMPANY (US) 1998-03-05 — — WO disclosed
EP-0825164-A2 Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides ELI LILLY AND COMPANY (US) 1998-02-25 — — EP disclosed
WO-1997026300-A1 COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED INDANE LIBRARIES ELI LILLY AND COMPANY (US) 1997-07-24 — — WO disclosed
CN-1097423-A Quinolone-and naphthyridonecarboxylic acid derivatives BAYER AG (DE) 1995-01-18 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 KAT6A 4294/4885ALDH1A1 1628/4885ALOX15 1190/4885
US-12338243-B2 P2X7 modulators P2RX7, P2RX4, P2RX1 KAT6A 4777/4885ALDH1A1 1107/4885ALOX15 989/4885
US-11708344-B2 Flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease CCNE2, CCNE1, CCNT1 KAT6A 2667/4885ALDH1A1 455/4885ALOX15 2472/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 KAT6A 4294/4885ALDH1A1 1628/4885ALOX15 1190/4885
US-20230074887-A1 FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE CCNE2, CCNE1, CCNT1 KAT6A 2667/4885ALDH1A1 455/4885ALOX15 2472/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 KAT6A 4294/4885ALDH1A1 1628/4885ALOX15 1190/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.