Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734720 | 1.00 | ITGB1 (0.46) | ITGB1ITGA4L3MBTL1CA2CA1 | |
| SCHEMBL7742548 | 0.91 | L3MBTL1 (0.42) | ITGB1ITGA4L3MBTL1GAARAB9A | |
| SCHEMBL7742545 | 0.91 | L3MBTL1 (0.42) | ITGB1ITGA4L3MBTL1GAARAB9A | |
| SCHEMBL4873894 | 0.80 | GAA (0.52) | L3MBTL1GAARAB9A | |
| SCHEMBL12158277 | 0.79 | LMNA (0.61) | L3MBTL1CA2CA1GAARAB9A | |
| SCHEMBL16840374 | 0.76 | ITGB1 (0.40) | ITGB1ITGA4L3MBTL1CA2LMNA | |
| SCHEMBL20299887 | 0.73 | TAS1R3 (0.45) | L3MBTL1CA2CA1GAARAB9A | |
| SCHEMBL28940166 | 0.73 | TAS1R3 (0.45) | L3MBTL1CA2CA1GAARAB9A | |
| SCHEMBL15235709 | 0.72 | TAS1R3 (0.44) | L3MBTL1GAARAB9ATAS1R3TAS1R1 | |
| SCHEMBL9045259 | 0.72 | L3MBTL1 (0.48) | L3MBTL1CA2CA1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |