SCHEMBL7735137

SCHEMBL7735137

CCCc1cc(F)c(C(F)(F)Oc2ccc(-c3cc(F)c(C(F)(F)F)c(F)c3)cc2)c(F)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.35
PPARG P37231 1/20 0.34
PPARD Q03181 1/20 0.34
PPARA Q07869 1/20 0.34
RARB P10826 3/20 0.33
RARA P10276 2/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
KIF11 P52732 1/20 0.33
PRMT6 Q96LA8 1/20 0.32
FFAR4 Q5NUL3 4/20 0.32
SERPINE1 P05121 1/20 0.31
RXRA P19793 1/20 0.31
RXRB P28702 1/20 0.31
RXRG P48443 1/20 0.31
RARG P13631 1/20 0.31
NPC1 O15118 1/20 0.31
TP53 P04637 1/20 0.31
PKM P14618 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7732784 0.93 RARB (0.33) PPARGPPARDPPARARARBRARA
SCHEMBL7730036 0.92 RARB (0.37) DAOPPARGPPARDPPARARARB
SCHEMBL7722828 0.91 RARB (0.41) DAOPPARGPPARARARBRARA
SCHEMBL7730459 0.90 DAO (0.38) DAOPPARGPPARARAB9ATHRB
SCHEMBL7728916 0.90 FFAR4 (0.36) PPARDPPARARARBRARACYP11B1
SCHEMBL13002204 0.89 RARB (0.36) RARBRARACYP11B1CYP11B2KIF11
SCHEMBL7732093 0.89 PRMT6 (0.36) PPARGPPARDPPARARARBRARA
SCHEMBL15786639 0.88 MAOB (0.40) PPARGPPARDPPARARARBRARA
SCHEMBL13002343 0.88 ALOX5AP (0.38) DAOPPARDRARBFFAR4GRM2
SCHEMBL7722816 0.88 CTSS (0.33) RARBRARACYP11B1CYP11B2KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed