Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | EDNRA | P25101 | 8/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344888 | 0.78 | CA2 (0.51) | CA2CA1CA9EDNRAFTO | |
| SCHEMBL6994641 | 0.76 | CDK2 (0.53) | CA2CDK2CA1CA9FTO | |
| SCHEMBL7735396 | 0.76 | CDK2 (0.62) | CA2CDK2CA1CA9FTO | |
| SCHEMBL9138970 | 0.75 | CDK2 (0.78) | CA2CDK2CA1CA9FTO | |
| SCHEMBL108421 | 0.75 | CA2 (1.00) | CA2CDK2CA1CA9EDNRA | |
| SCHEMBL21917567 | 0.75 | PLAU (0.46) | MAPK1KDM4ETSHRCYP1A2CYP2C19 | |
| SCHEMBL31399697 | 0.74 | ROCK2 (0.63) | MAPK1KDM4ETSHRCYP1A2CYP2C19 | |
| SCHEMBL8489706 | 0.74 | CYP1A2 (0.52) | MAPK1TSHRCYP1A2CYP2C19HTT | |
| SCHEMBL11407481 | 0.73 | CA2 (0.96) | CA2CDK2CA1CA9EDNRA | |
| SCHEMBL13223071 | 0.72 | CDK2 (0.62) | CA2CDK2CA1CA9FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558479-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024017858-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |