SCHEMBL7736866

SCHEMBL7736866

CC(Cl)OC(=O)N(C)c1ncccc1COC(=O)CN(C)C(=O)OC(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CASP3 P42574 2/20 0.32
▸ SENP8 Q96LD8 2/20 0.32
▸ SENP7 Q9BQF6 2/20 0.32
▸ SENP6 Q9GZR1 2/20 0.32
▸ NPC1 O15118 2/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ TACR1 P25103 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ GBA1 P04062 1/20 0.31
▸ HTR2C P28335 1/20 0.30
▸ SLC6A4 P31645 1/20 0.30
▸ CHRM2 P08172 1/20 0.30
▸ CHRM4 P08173 1/20 0.30
▸ CHRM5 P08912 1/20 0.30
▸ CHRM1 P11229 1/20 0.30
▸ CHRM3 P20309 1/20 0.30
▸ PTK2 Q05397 1/20 0.30
▸ GLA P06280 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29867943 1.00 CASP3 (0.32) CASP3SENP8SENP7SENP6NPC1
SCHEMBL17485426 0.92 NPC1 (0.35) CASP3SENP8SENP7SENP6NPC1
SCHEMBL20712022 0.89 CASP3 (0.32) CASP3SENP8SENP7SENP6NPC1
SCHEMBL26024103 0.88 HTT (0.35) CASP3SENP8SENP7SENP6NPC1
SCHEMBL22636487 0.87 CASP3 (0.33) CASP3SENP8SENP7SENP6NPC1
SCHEMBL31172125 0.87 CASP3 (0.33) CASP3SENP8SENP7SENP6NPC1
SCHEMBL20711945 0.87 MEN1 (0.35) NPC1RAB9ASMN1; SMN2L3MBTL1
SCHEMBL28931092 0.86 GBA1 (0.35) CASP3SENP8SENP7SENP6NPC1
SCHEMBL25020373 0.85 CASP3 (0.32) CASP3SENP8SENP7SENP6NPC1
SCHEMBL29773056 0.85 CASP3 (0.32) CASP3SENP8SENP7SENP6NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4565582-A1 PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM MONOSULFATE Icrom SpA (IT) 2025-06-11 — — EP claimed
WO-2024028711-A1 PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM MONOSULFATE ICROM S.P.A. (IT) 2024-02-08 — — WO claimed
EP-4565582-A1 PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM MONOSULFATE Icrom SpA (IT) 2025-06-11 — — EP disclosed
US-20250145610-A1 CRYSTALLINE FORM OF ISAVUCONAZONIUM SULFATE AND A PROCESS FOR ITS PREPARATION ALIVUS LIFE SCIENCES LIMITED (IN) 2025-05-08 — — US disclosed
US-20250092053-A1 TRIAZOLE-SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AS CGAS INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2025-03-20 — — US disclosed
US-12247033-B2 Triazole-substituted imidazo[1,2-a]pyrimidines as cGAS inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2025-03-11 — — US disclosed
WO-2025008993-A1 Improved process for the preparation of Glycine, N-methyl-, [2-[[[1-[1-((2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester, sulfate (1:1) MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) 2025-01-09 — — WO disclosed
CN-119192067-A Preparation method of isaconazole side chain intermediate C1 山东齐都药业有限公司 2024-12-27 — — CN disclosed
EP-4472978-A1 CRYSTALLINE FORM OF ISAVUCONAZONIUM SULFATE AND A PROCESS FOR ITS PREPARATION Glenmark Life Sciences Limited (IN) 2024-12-11 — — EP disclosed
WO-2024189550-A1 PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM SULFATE AND ITS CRYSTALLINE FORMS APITORIA PHARMA PRIVATE LIMITED (IN) 2024-09-19 — — WO disclosed
WO-2024189550-A1 PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM SULFATE AND ITS CRYSTALLINE FORMS APITORIA PHARMA PRIVATE LIMITED (IN) 2024-09-19 — — WO disclosed
WO-2020227337-A1 PRODRUG COMPOUNDS BRISTOL-MYERS SQUIBB COMPANY (US) 2020-11-12 — — WO disclosed
WO-2016016766-A2 A PROCESS FOR THE PREPARATION OF ISAVUCONAZONIUM OR ITS SALT THEREOF WOCKHARDT LIMITED (IN) 2016-02-04 — — WO disclosed
US-7459561-B2 N-substituted carbamoyloxyalkyl-azolium derivatives BASILEA PHARMACEUTICA AG (CH) 2008-12-02 — — US disclosed
US-7189858-B2 N-phenyl substituted carbamoyloxyalkyl-azolium derivatives BASILEA PHARMACEUTICA AG (CH) 2007-03-13 — — US disclosed
US-7189858-B2 N-phenyl substituted carbamoyloxyalkyl-azolium derivatives BASILEA PHARMACEUTICA AG (CH) 2007-03-13 — — US disclosed
US-20070027322-A1 N-substituted carbamoyloxyalkyl-azolium derivatives BASILEA PHARMACEUTICA INTERNATIONAL LTD. (CH) 2007-02-01 — — US disclosed
US-20070027322-A1 N-substituted carbamoyloxyalkyl-azolium derivatives BASILEA PHARMACEUTICA INTERNATIONAL LTD. (CH) 2007-02-01 — — US disclosed
US-6812238-B1 WATER SOLUBLE FUNGICIDES FOR SYSTEMIC MYCOSES; ORAL AND PARENTERAL ADMINISTRATION BASILEA PHARMACEUTICA AG (CH) 2004-11-02 — — US disclosed
US-6812238-B1 WATER SOLUBLE FUNGICIDES FOR SYSTEMIC MYCOSES; ORAL AND PARENTERAL ADMINISTRATION BASILEA PHARMACEUTICA AG (CH) 2004-11-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247033-B2 Triazole-substituted imidazo[1,2-a]pyrimidines as cGAS inhibitors CGAS, SSB, STING1 CASP3 1850/4885SENP8 4057/4885SENP7 3939/4885
US-20250145610-A1 CRYSTALLINE FORM OF ISAVUCONAZONIUM SULFATE AND A PROCESS FOR ITS PREPARATION STS, MPST, SI CASP3 2584/4885SENP8 1191/4885SENP7 811/4885
US-20070027322-A1 N-substituted carbamoyloxyalkyl-azolium derivatives ERG28, CYP51A1, NAALAD2 CASP3 69/4885SENP8 1858/4885SENP7 2234/4885
US-20250092053-A1 TRIAZOLE-SUBSTITUTED IMIDAZO[1,2-A]PYRIMIDINES AS CGAS INHIBITORS CGAS, SSB, STING1 CASP3 1850/4885SENP8 4057/4885SENP7 3939/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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