Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 7/20 | 0.49 |
| ▸ | NOS2 | P35228 | 5/20 | 0.49 |
| ▸ | NOS3 | P29474 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2834751 | 0.92 | NOS1 (0.44) | NOS1NOS2NOS3 | |
| SCHEMBL8330574 | 0.91 | NOS1 (0.61) | NOS1NOS2NOS3BACE1 | |
| SCHEMBL8330686 | 0.91 | NOS1 (0.57) | NOS1NOS2NOS3BACE1 | |
| SCHEMBL2836244 | 0.91 | NOS1 (0.59) | NOS1NOS2NOS3 | |
| SCHEMBL17721483 | 0.88 | NOS1 (0.52) | NOS1NOS2NOS3 | |
| SCHEMBL7737309 | 0.86 | BACE1 (0.48) | NOS1NOS2NOS3BACE1 | |
| SCHEMBL2836816 | 0.85 | NOS1 (0.44) | NOS1NOS2NOS3BACE1 | |
| SCHEMBL17708566 | 0.85 | NOS1 (0.49) | NOS1NOS2NOS3 | |
| SCHEMBL19379329 | 0.85 | NOS2 (0.45) | NOS1NOS2NOS3BACE1 | |
| SCHEMBL19379168 | 0.85 | BACE1 (0.49) | NOS1NOS2NOS3BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8932842-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2015-01-13 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2013-02-14 | — | — | US | disclosed |
| US-8278084-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278084-B2 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NORTHWESTERN UNIVERSITY (US) | 2012-10-02 | — | — | US | disclosed |
| WO-2010093787-A2 | AMINOPYRIDINE DIMER COMPOUNDS, COMPOSITIONS AND RELATED METHODS FOR NEURONAL NITRIC OXIDE SYNTHASE INHIBITION | NORTHWESTERN UNIVERSITY (US) | 2010-08-19 | — | — | WO | disclosed |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-12 | — | — | US | disclosed |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-08-12 | — | — | US | disclosed |
| US-5972975-A | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1996018616-A1 | SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040359-A1 | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition | NOS2, NOS1, NOS3 | NOS1 2/4885NOS2 1/4885NOS3 3/4885 |
| US-20100203613-A1 | Aminopyridine Dimer Compounds, Compositions and Related Methods for Neuronal Nitric Oxide Synthase Inhibition | NOS2, NOS1, NOS3 | NOS1 2/4885NOS2 1/4885NOS3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.