Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ESPL1 | Q14674 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738172 | 0.94 | KMT2A (0.45) | KMT2ALMNATDP1MEN1MAPT | |
| SCHEMBL7740549 | 0.89 | KMT2A (0.56) | KMT2ALMNATDP1MEN1MAPT | |
| Iodide SCHEMBL6537188 | 0.89 | MAPT (0.48) | KMT2ALMNATDP1MEN1MAPT | |
| SCHEMBL7750100 | 0.84 | LMNA (0.47) | KMT2ALMNATDP1MEN1MAPT | |
| SCHEMBL7740556 | 0.81 | ACHE (0.41) | KMT2ALMNATDP1MEN1MAPT | |
| SCHEMBL15130203 | 0.80 | KCNJ1 (0.37) | KMT2ALMNATDP1MEN1MAPT | |
| SCHEMBL10082444 | 0.78 | MAPT (0.61) | KMT2ALMNATDP1MEN1MAPT | |
| SCHEMBL2614432 | 0.77 | MAPT (0.69) | KMT2ALMNATDP1MEN1MAPT | |
| Iodide SCHEMBL6537514 | 0.76 | MAPT (0.64) | KMT2ALMNATDP1MEN1MAPT | |
| SCHEMBL7750107 | 0.76 | MAPT (0.46) | KMT2ALMNATDP1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413607-B1 | Cyanine dyes | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1088857-A1 | CYANINE DYE | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2001-04-04 | — | — | EP | disclosed |