Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.98 |
| ▸ | S1PR3 | Q99500 | 18/20 | 0.98 |
| ▸ | S1PR4 | O95977 | 12/20 | 0.98 |
| ▸ | S1PR5 | Q9H228 | 11/20 | 0.98 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817298 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL4817638 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL12084862 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL3726781 | 0.90 | S1PR1 (0.80) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL13614240 | 0.88 | S1PR1 (0.81) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL4825689 | 0.88 | S1PR1 (0.78) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL4821551 | 0.87 | S1PR1 (0.80) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL6428128 | 0.87 | S1PR1 (0.76) | S1PR1S1PR3S1PR4S1PR5S1PR2 | |
| SCHEMBL4821435 | 0.87 | S1PR1 (0.76) | S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL4809850 | 0.87 | S1PR1 (0.79) | S1PR1S1PR3S1PR4S1PR5S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150087720-A1 | Dosage Regimen of an S1P Receptor Agonist | NOVARTIS AG (CH) | 2015-03-26 | — | — | US | claimed |
| US-20120071446-A1 | DOSAGE REGIMEN OF AN S1P RECEPTOR AGONIST | KOVARIK JOHN M (CH) | 2012-03-22 | — | — | US | claimed |
| US-7910741-B2 | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-03-22 | — | — | US | claimed |
| US-20090275553-A1 | DOSAGE REGIMEN OF AN S1P RECEPTOR AGONIST | KOVARIK JOHN M | 2009-11-05 | — | — | US | claimed |
| US-20080221200-A1 | Combination of Organic Compounds | ALLISON MALCOLM | 2008-09-11 | — | — | US | claimed |
| EP-1940388-A2 | DPP IV INHIBTOR FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND GRAFT REJECTION | Novartis AG (CH) | 2008-07-09 | — | — | EP | claimed |
| WO-2007041368-A2 | DPP IV INHIBITOR FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES AND GRAFT REJECTION | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | claimed |
| US-20040067853-A1 | Sulfonamide derivative-containing agricultural and horticultural composition | NAKAYAMA MASAHARU (JP) | 2004-04-08 | — | — | US | claimed |
| US-20040023938-A1 | Sulfonamide derivatives | TABUCHI TAKANORI (JP) | 2004-02-05 | — | — | US | claimed |
| EP-1351570-A1 | SULFONAMIDE DERIVATIVE-CONTAINING AGRICULTURAL AND HORTICULTURAL COMPOSITION | Sumitomo Chemical Takeda Agro Company, Limited (JP) | 2003-10-15 | — | — | EP | claimed |
| WO-2002054867-A1 | SULFONAMIDE DERIVATIVE-CONTAINING AGRICULTURAL AND HORTICULTURAL COMPOSITION | SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) | 2002-07-18 | — | — | WO | claimed |
| EP-1174028-A1 | SULFONAMIDE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2002-01-23 | — | — | EP | claimed |
| US-20220031609-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2022-02-03 | — | — | US | disclosed |
| US-20200237690-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2020-07-30 | — | — | US | disclosed |
| US-20190175527-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2019-06-13 | — | — | US | disclosed |
| US-20170290787-A1 | Organic Compounds | NOVARTIS AG (CH) | 2017-10-12 | — | — | US | disclosed |
| WO-2002076995-A2 | 2-AMINO-PROPANOL DERIVATIVES | NOVARTIS AG (CH) | 2002-10-03 | — | — | WO | disclosed |
| WO-2002054867-A1 | SULFONAMIDE DERIVATIVE-CONTAINING AGRICULTURAL AND HORTICULTURAL COMPOSITION | SUMITOMO CHEMICAL TAKEDA AGRO COMPANY, LIMITED (JP) | 2002-07-18 | — | — | WO | disclosed |
| CN-1349381-A | Sulfonamide derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-05-15 | — | — | CN | disclosed |
| EP-1174028-A1 | SULFONAMIDE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2002-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190175527-A1 | ORGANIC COMPOUNDS | GPR119, OPRM1, FFAR1 | S1PR1 33/4885S1PR3 101/4885S1PR4 124/4885 |
| US-20040067853-A1 | Sulfonamide derivative-containing agricultural and horticultural composition | NAT1, NR4A1, MRM1 | S1PR1 671/4885S1PR3 1286/4885S1PR4 1044/4885 |
| US-20080221200-A1 | Combination of Organic Compounds | DPP4, DPP3, DPP7 | S1PR1 1727/4885S1PR3 1326/4885S1PR4 943/4885 |
| US-20040023938-A1 | Sulfonamide derivatives | FPR1, MRM1, SULT1E1 | S1PR1 214/4885S1PR3 427/4885S1PR4 542/4885 |
| US-20220031609-A1 | ORGANIC COMPOUNDS | GPR119, OPRM1, FFAR1 | S1PR1 33/4885S1PR3 101/4885S1PR4 124/4885 |
| US-20090275553-A1 | DOSAGE REGIMEN OF AN S1P RECEPTOR AGONIST | S1PR1, S1PR2, S1PR4 | S1PR1 1/4885S1PR3 5/4885S1PR4 3/4885 |
| US-20150087720-A1 | Dosage Regimen of an S1P Receptor Agonist | S1PR1, S1PR2, S1PR4 | S1PR1 1/4885S1PR3 5/4885S1PR4 3/4885 |
| US-20170290787-A1 | Organic Compounds | GPR119, OPRM1, FFAR1 | S1PR1 33/4885S1PR3 101/4885S1PR4 124/4885 |
| US-20200237690-A1 | ORGANIC COMPOUNDS | GPR119, OPRM1, FFAR1 | S1PR1 33/4885S1PR3 101/4885S1PR4 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.