Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 15/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 14/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 14/20 | 0.59 |
| ▸ | PTGIR | P43119 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690714 | 0.80 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CPTGIRADRA1D | |
| SCHEMBL6159235 | 0.73 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CPTGIR | |
| SCHEMBL5654958 | 0.73 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CKDM1A | |
| SCHEMBL6969768 | 0.73 | MAPT (0.42) | ADRA2C | |
| SCHEMBL2525631 | 0.71 | ADRA2A (0.56) | ADRA2AADRA2BADRA2C | |
| SCHEMBL6159740 | 0.69 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CPTGIR | |
| SCHEMBL5806235 | 0.66 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CPTGIR | |
| SCHEMBL27642289 | 0.66 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CPTGIRADRA1D | |
| SCHEMBL7980595 | 0.65 | MAPT (0.62) | KDM1A | |
| SCHEMBL5658117 | 0.65 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CPTGIRKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417186-B1 | TREATING PAIN, URINARY TRACT INFECTIONS, INFLAMMATION, RESPIRATORY DISEASE STATES FROM ALLERGIES OR ASTHMA, EDEMA FORMATION OR HYPOTENSIVE VASCULAR DISEASES. | SYNTEX (U.S.A.) LLC | 2002-07-09 | — | — | US | disclosed |