Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | LGMN | Q99538 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975910 | 0.80 | MAPT (0.45) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL20631 | 0.78 | MAPT (0.61) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL20631313 | 0.76 | LMNA (0.61) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL16209945 | 0.76 | MAPT (0.65) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL7738762 | 0.73 | ADRA2A (0.59) | ADRA2C | |
| SCHEMBL28298439 | 0.72 | PIK3CD (0.41) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL14320289 | 0.72 | PIK3R1 (0.59) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL6383636 | 0.72 | ALDH1A1 (0.50) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL6962007 | 0.72 | SERPINH1 (0.41) | MAPTALDH1A1MAPK1TDP1LMNA | |
| SCHEMBL4689823 | 0.72 | ALDH1A1 (0.52) | MAPTALDH1A1GAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339694-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002040453-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-23 | — | — | WO | disclosed |