Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738876 | 0.87 | ALDH1A1 (0.41) | LMNAKDM4ENAMPTMAPK1MEN1 | |
| SCHEMBL7734198 | 0.84 | TSHR (0.34) | SYKLMNAKDM4ENAMPTBRD4 | |
| SCHEMBL7738995 | 0.84 | JAK2 (0.35) | SYKLMNAKDM4ENAMPTBRD4 | |
| SCHEMBL7740422 | 0.80 | SYK (0.40) | SYKLMNANAMPTBRD4MAPKAPK2 | |
| SCHEMBL27493987 | 0.78 | ALDH1A1 (0.33) | SYKLMNAMEN1ALDH1A1MAPT | |
| SCHEMBL7734201 | 0.78 | SYK (0.33) | SYKBRD4PCSK9CA12CA1 | |
| SCHEMBL6676282 | 0.75 | KCNA5 (0.41) | LMNANAMPTTSHRMAPKAPK2POLB | |
| SCHEMBL23118891 | 0.75 | KLKB1 (0.40) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL29792605 | 0.75 | KLKB1 (0.40) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7740426 | 0.73 | PDK1 (0.40) | SYKNAMPTBRD4PCSK9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |