Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738864 | 0.87 | SYK (0.35) | ALDH1A1MAPTNPSR1RAB9ALMNA | |
| SCHEMBL7734198 | 0.79 | TSHR (0.34) | ALDH1A1MAPTNPSR1RAB9ALMNA | |
| SCHEMBL7738995 | 0.79 | JAK2 (0.35) | LMNAKDM4EMAPK1NAMPT | |
| SCHEMBL29792605 | 0.70 | KLKB1 (0.40) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23118891 | 0.70 | KLKB1 (0.40) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5386906 | 0.70 | ALDH1A1 (0.56) | ALDH1A1MAPTNPSR1NPC1RAB9A | |
| SCHEMBL7740422 | 0.70 | SYK (0.40) | ALDH1A1MAPTNPSR1RAB9ARXFP1 | |
| SCHEMBL7734201 | 0.69 | SYK (0.33) | MAPK1 | |
| SCHEMBL6757735 | 0.68 | SMN1; SMN2 (0.61) | ALDH1A1MAPTNPSR1NPC1RAB9A | |
| SCHEMBL7740426 | 0.67 | PDK1 (0.40) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |