Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740426 | 0.84 | PDK1 (0.40) | SYKNAMPTPDK1PDK2PDK3 | |
| SCHEMBL7740478 | 0.83 | SYK (0.37) | SYKALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7740424 | 0.83 | MEN1 (0.36) | SYKALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7738864 | 0.80 | SYK (0.35) | SYKALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7740420 | 0.78 | SYK (0.37) | SYKALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7740427 | 0.77 | NOS1 (0.38) | SYK | |
| SCHEMBL7247258 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KMT2ALMNAGAAMAPKAPK2 | |
| SCHEMBL6677097 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MAPTNAMPTGAAMAPKAPK2 | |
| SCHEMBL22044738 | 0.74 | NAMPT (0.44) | SYKALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6675952 | 0.73 | CYP2C9 (0.45) | SYKALDH1A1MAPTLMNANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414005-B1 | BRAIN DISORDERS; ALZHEIMER'S DISEASE; PARKINSON'S DISEASE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-07-02 | — | — | US | disclosed |
| EP-1043312-A1 | HETEROCYCLIC COMPOUNDS HAVING NOS INHIBITORY ACTIVITIES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-10-11 | — | — | EP | disclosed |